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Disruptive Science

When Bacteria Outsmart Antibiotics, Surveillance Can Help Battle Resistance

When Bacteria Outsmart Antibiotics, Surveillance Can Help Battle Resistance

When Bacteria Outsmart Antibiotics,...

Since bacteria grow and reproduce quickly, they also quickly adapt on a genetic level to pressures from the outside through genetic mutations and even through acquiring genes from other bacteria. If those genetic changes make the bacteria resistant to a given antibiotic, then it will survive when...

 New Research Sheds Light on What Inputs Cells Need to Proliferate

New Research Sheds Light on What Inputs Cells Need to Proliferate

New Research Sheds Light on What Inputs Cells...

A group of researchers in Pfizer’s Oncology Research & Development group are shedding new light on one of the most important of those signaling pathways — the “mechanistic target of rapamycin complex 1”, or mTORC1. And the findings, published in Cell Reports, could have important implications...

How Fragment-Based Drug Screening Is Like the ‘Tetris’ of Drug Design

How Fragment-Based Drug Screening Is Like the ‘Tetris’ of Drug Design

How Fragment-Based Drug Screening Is Like the ...

In recent years, an alternative approach to finding drug candidates has emerged, known as fragment-based drug design.  With the fragment-based approach, you’re starting with a smaller pool of much simpler compounds about half the size of HTS molecules — mere fragments. 

Decoding Science: Cytokines

Decoding Science: Cytokines

Decoding Science: Cytokines

From the Greek “cyto” for cell and “kinos” for movement, cytokines orchestrate the immune system’s activity, and may be the key to understanding and treating autoimmune disorders.

Cryo-Electron Microscope Opens Resolution Revolution for Biological Imaging

Cryo-Electron Microscope Opens Resolution Revolution for Biological Imaging

Cryo-Electron Microscope Opens Resolution...

The cryo-electron microscope, or cryo-EM, is allowing scientists to image structures as small as viruses and ribosomes — the part of the cell where proteins are synthesized. More importantly, it does this without the need to turn the samples into crystals — the often tricky step needed when using...

When Diversity Means Better Medicine

When Diversity Means Better Medicine

When Diversity Means Better Medicine

By tapping into more diverse genomes, researchers are gaining novel insights into disease and drug safety. 

A New Frontier for AI: Helping Scientists Develop Potential New Medicines

A New Frontier for AI: Helping Scientists Develop Potential New Medicines

A New Frontier for AI: Helping Scientists...

Austin Huang, Associate Director and the Biomedical Data Science lead in Pfizer’s Genome Sciences and Technologies group, explains the role of artificial intelligence in drug development.

One of Mom’s Many Gifts to Her Baby: Maternal Vaccination

One of Mom’s Many Gifts to Her Baby: Maternal Vaccination

One of Mom’s Many Gifts to Her Baby: Maternal...

In recent years, maternal immunization has been steadily gaining acceptance as a means to pass infection-fighting antibodies to newborns. Current research shows that vaccines are safe for pregnant women. 

Fixing Broken Body Clocks

Fixing Broken Body Clocks

Fixing Broken Body Clocks

Every living being from fungi to frogs has an internal clock that normally runs on a 24-hour cycle.  In humans, this master clock resides in a tiny region of the brain’s hypothalamus and controls everything from hunger and sleep patterns to daily hormone fluctuations and body temperature.In...

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