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Disruptive Science

Inside the Science of Making a Better Pill

Inside the Science of Making a Better Pill

Inside the Science of Making a Better Pill

Turning the active ingredients of a medicine into a tablet or liquid that is effective, safe and convenient is a crucial step in the development of a medicine, and the complexity of the process is often veiled behind the tidy final product we see. Having a medicine that is the right shape, taste,...

How Immuno-Oncology Taps Into the Body’s Own Immune System to Fight Cancer

How Immuno-Oncology Taps Into the Body’s Own Immune System to Fight Cancer

How Immuno-Oncology Taps Into the Body’s Own...

One of the most important advances in cancer therapies is a field known as immuno-oncology, which uses methods that tap into a patient’s own immune system to detect and destroy cancer cells. Experts predict that immuno-oncology will become one of the pillars of cancer treatment, alongside more...

When Bacteria Outsmart Antibiotics, Surveillance Can Help Battle Resistance

When Bacteria Outsmart Antibiotics, Surveillance Can Help Battle Resistance

When Bacteria Outsmart Antibiotics,...

Since bacteria grow and reproduce quickly, they also quickly adapt on a genetic level to pressures from the outside through genetic mutations and even through acquiring genes from other bacteria. If those genetic changes make the bacteria resistant to a given antibiotic, then it will survive when...

 New Research Sheds Light on What Inputs Cells Need to Proliferate

New Research Sheds Light on What Inputs Cells Need to Proliferate

New Research Sheds Light on What Inputs Cells...

A group of researchers in Pfizer’s Oncology Research & Development group are shedding new light on one of the most important of those signaling pathways — the “mechanistic target of rapamycin complex 1”, or mTORC1. And the findings, published in Cell Reports, could have important implications...

How Fragment-Based Drug Screening Is Like the ‘Tetris’ of Drug Design

How Fragment-Based Drug Screening Is Like the ‘Tetris’ of Drug Design

How Fragment-Based Drug Screening Is Like the ...

In recent years, an alternative approach to finding drug candidates has emerged, known as fragment-based drug design.  With the fragment-based approach, you’re starting with a smaller pool of much simpler compounds about half the size of HTS molecules — mere fragments. 

Decoding Science: Cytokines

Decoding Science: Cytokines

Decoding Science: Cytokines

From the Greek “cyto” for cell and “kinos” for movement, cytokines orchestrate the immune system’s activity, and may be the key to understanding and treating autoimmune disorders.

Cryo-Electron Microscope Opens Resolution Revolution for Biological Imaging

Cryo-Electron Microscope Opens Resolution Revolution for Biological Imaging

Cryo-Electron Microscope Opens Resolution...

The cryo-electron microscope, or cryo-EM, is allowing scientists to image structures as small as viruses and ribosomes — the part of the cell where proteins are synthesized. More importantly, it does this without the need to turn the samples into crystals — the often tricky step needed when using...

When Diversity Means Better Medicine

When Diversity Means Better Medicine

When Diversity Means Better Medicine

By tapping into more diverse genomes, researchers are gaining novel insights into disease and drug safety. 

A New Frontier for AI: Helping Scientists Develop Potential New Medicines

A New Frontier for AI: Helping Scientists Develop Potential New Medicines

A New Frontier for AI: Helping Scientists...

Austin Huang, Associate Director and the Biomedical Data Science lead in Pfizer’s Genome Sciences and Technologies group, explains the role of artificial intelligence in drug development.

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