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Disruptive Science

Are Genetic Tweaks Made by Gene Therapy Handed Down to Offspring?

Are Genetic Tweaks Made by Gene Therapy Handed Down to Offspring?

Are Genetic Tweaks Made by Gene Therapy Handed...

The possibility of finding a treatment or even a cure for genetic disorders such as muscular dystrophy or hemophilia has taken a giant leap forward in recent years with the advent of gene therapy as a way to modify a defective gene or group of genes. ...

The Search for a ‘Liquid Biopsy’ and Other Advances to Diagnose Cancer

The Search for a ‘Liquid Biopsy’ and Other Advances to Diagnose Cancer

The Search for a ‘Liquid Biopsy’ and Other...

A liquid biopsy — a technology that attempts to diagnose a disease through a blood sample rather than by using a tissue sample collected through a traditional biopsy — is just one technology being explored to make cancer diagnosis faster and less invasive. ...

Metabolism and Immunology: Using Lessons From Metabolic Diseases to Treat Autoimmune Disorders

Metabolism and Immunology: Using Lessons From Metabolic Diseases to Treat Autoimmune Disorders

Metabolism and Immunology: Using Lessons From...

By regulating the metabolism of immune cells, researchers are uncovering novel ways to suppress inflammation and treat autoimmune diseases. ...

A Mountaineer Reaches for the ‘Everest’ of his Cancer Research Career

A Mountaineer Reaches for the ‘Everest’ of his Cancer Research Career

A Mountaineer Reaches for the ‘Everest’ of his...

New insights into the immune system are driving a recent resurgence in investigating vaccines that fight cancer tumors.  ...

Inside the Science of Making a Better Pill

Inside the Science of Making a Better Pill

Inside the Science of Making a Better Pill

Turning the active ingredients of a medicine into a tablet or liquid that is effective, safe and convenient is a crucial step in the development of a medicine, and the complexity of the process is often veiled behind the tidy final product we see. Having a medicine that is the right shape, taste,...

How Immuno-Oncology Taps Into the Body’s Own Immune System to Fight Cancer

How Immuno-Oncology Taps Into the Body’s Own Immune System to Fight Cancer

How Immuno-Oncology Taps Into the Body’s Own...

One of the most important advances in cancer therapies is a field known as immuno-oncology, which uses methods that tap into a patient’s own immune system to detect and destroy cancer cells. Experts predict that immuno-oncology will become one of the pillars of cancer treatment, alongside more...

When Bacteria Outsmart Antibiotics, Surveillance Can Help Battle Resistance

When Bacteria Outsmart Antibiotics, Surveillance Can Help Battle Resistance

When Bacteria Outsmart Antibiotics,...

Since bacteria grow and reproduce quickly, they also quickly adapt on a genetic level to pressures from the outside through genetic mutations and even through acquiring genes from other bacteria. If those genetic changes make the bacteria resistant to a given antibiotic, then it will survive when...

 New Research Sheds Light on What Inputs Cells Need to Proliferate

New Research Sheds Light on What Inputs Cells Need to Proliferate

New Research Sheds Light on What Inputs Cells...

A group of researchers in Pfizer’s Oncology Research & Development group are shedding new light on one of the most important of those signaling pathways — the “mechanistic target of rapamycin complex 1”, or mTORC1. And the findings, published in Cell Reports, could have important implications...

How Fragment-Based Drug Screening Is Like the ‘Tetris’ of Drug Design

How Fragment-Based Drug Screening Is Like the ‘Tetris’ of Drug Design

How Fragment-Based Drug Screening Is Like the ...

In recent years, an alternative approach to finding drug candidates has emerged, known as fragment-based drug design.  With the fragment-based approach, you’re starting with a smaller pool of much simpler compounds about half the size of HTS molecules — mere fragments. 

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