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Disruptive Science

Drug Makers Recruit Patients With Specific DNA for Precision Medicine Trials

Drug Makers Recruit Patients With Specific DNA for Precision Medicine Trials

Drug Makers Recruit Patients With Specific DNA...

Precision medicine is an evolving field focused on bringing more precisely targeted medicine to more precisely targeted patients. The goal is to identify specific subgroups of patients, and match them to a customized treatment that potentially could be transformative. Advances in genetic analysis...

Getting a Medicine to the Brain Is a Major Challenge in Drug Design: How This Scientist Solved It

Getting a Medicine to the Brain Is a Major Challenge in Drug Design: How This Scientist Solved It

Getting a Medicine to the Brain Is a Major...

For cancer patients who have been treated with a particular medicine for some time, one of the hurdles many of them face is the tumor developing a resistance to the medicine. It’s a cruel twist that can affect patients being treated for non-small cell lung cancer, which can mutate and begin...

‘Bucket Brigades’ Gone Rogue: A New Path to Shutting Down Cancer Growth

‘Bucket Brigades’ Gone Rogue: A New Path to Shutting Down Cancer Growth

‘Bucket Brigades’ Gone Rogue: A New Path to...

A critical pathway in our cells acts like a bucket brigade, efficiently passing on signals that control cellular growth. But what happens when one set of “hands” on the line goes rogue? ...

The Action-Packed Search for Stability: A Breakthrough in the Fight Against RSV

The Action-Packed Search for Stability: A Breakthrough in the Fight Against RSV

The Action-Packed Search for Stability: A...

Respiratory syncytial virus (RSV), a major global childhood infectious disease without a vaccine, kills approximately 120,000 infants a year worldwide. It’s the most common reason infants are hospitalized. Additionally, RSV sickens millions of elderly people each year.  ...

Better, Faster, Smaller: How an Advance in Microfluidics Can Speed Up Drug Discovery

Better, Faster, Smaller: How an Advance in Microfluidics Can Speed Up Drug Discovery

Better, Faster, Smaller: How an Advance in...

Before preparing a new recipe for 20 guests at Thanksgiving, the smart cook starts small, making the dish for their immediate family to test things out before the big holiday dinner. What does a scientist do when attempting to discover a molecule that has the properties that potentially could be...

When Cancers Develop Resistance, ‘Stealthy’ Medicines Can Help

When Cancers Develop Resistance, ‘Stealthy’ Medicines Can Help

When Cancers Develop Resistance, ‘Stealthy’...

In the quest for better cancer therapies, Dr. Martin Edwards is one of the scientists on the frontlines informally known as “drug hunters.” His preoccupation these days is hunting for medicines that are more “stealthy” in their fight against cancer tumors—especially tumors that are resistant to...

How Finland’s Unique Genetic Heritage Is Being Used to Study the Links Between Genes and Diseases

How Finland’s Unique Genetic Heritage Is Being Used to Study the Links Between Genes and Diseases

How Finland’s Unique Genetic Heritage Is Being...

The unique genetic heritage of the Finns — marked by repeated population bottlenecks and isolation from their neighbors in northern Europe — is helping scientists embark on a search for the complex links between genes and diseases.  ...

An On/Off Switch for Genes: Meet Zinc Finger Transcription Factors

An On/Off Switch for Genes: Meet Zinc Finger Transcription Factors

An On/Off Switch for Genes: Meet Zinc Finger...

Scientists made a surprising discovery in 1985 while studying the African clawed frog. Along the frog’s DNA, they noticed elongated loops resembling fingers that tightly gripped tiny segments of genes. They soon learned that these “zinc fingers” (so called because they’re bound by a zinc ion) are...

Women in Science Up Close and Personal, Part 5: Success Strategies

Women in Science Up Close and Personal, Part 5: Success Strategies

Women in Science Up Close and Personal, Part 5:...

In the fifth of our series honoring women in science, Pfizer researchers share their advice for young women who are launching scientific careers — and for the organizations hoping to hire and keep them.  ...

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