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Disruptive Science

Scientist Embraces the ‘Ick’ Factor to Develop a New Tool Against a Dangerous Pathogen

Scientist Embraces the ‘Ick’ Factor to Develop a New Tool Against a Dangerous Pathogen

Scientist Embraces the ‘Ick’ Factor to Develop...

Developing a vaccine to prevent the devastating disease caused by Clostridium difficile requires a reliable and sensitive test to diagnose the dangerous disease causing toxins produced by C. diff — and it also required scientists to figure out how to detect the toxins in stool...

That Which is Old is New Again: Phenotypic Drug Discovery Makes a Comeback

That Which is Old is New Again: Phenotypic Drug Discovery Makes a Comeback

That Which is Old is New Again: Phenotypic Drug...

Scientists return to a classic model of drug discovery in an attempt to find novel medicines, while adding a modern spin. ...

Tumor-Typing: A New Way of Assessing Cancer Treatment Options

Tumor-Typing: A New Way of Assessing Cancer Treatment Options

Tumor-Typing: A New Way of Assessing Cancer...

A method of analyzing tumors could inform response to immunotherapies.  ...

Attacking Cancer Cells That Develop Resistance

Attacking Cancer Cells That Develop Resistance

Attacking Cancer Cells That Develop Resistance

When cancer patients receive therapy for an extended time, they often face the specter of drug resistance as tumor cells mutate and find ways to evade the cancer-killing medicines. ...

Using the Dr. Jekyll of Chemical Compounds to Advance Drug Synthesis

Using the Dr. Jekyll of Chemical Compounds to Advance Drug Synthesis

Using the Dr. Jekyll of Chemical Compounds to...

Sulfuryl fluoride gas is the chemical equivalent of Mr. Hyde. Like the fictional monster, it’s dangerous and difficult to work with. But by inventing a process that creates a new substance called [4-(Acetylamino)phenyl]-ImidodiSulfuryl diFluoride, referred to as AISF, scientists are replacing the...

The ‘Ecology’ of Cancer: Studying the ‘Soil’ that Enables the Disease to Thrive

The ‘Ecology’ of Cancer: Studying the ‘Soil’ that Enables the Disease to Thrive

The ‘Ecology’ of Cancer: Studying the ‘Soil’...

Borrowing from the field of ecology, cancer is now being examined in terms of the relationship between a cancer cell and the traits of its local environment — the tissue, cells and blood vessels — that help it to thrive. ...

How to Deal Dangerous Proteins a Knockout Blow

How to Deal Dangerous Proteins a Knockout Blow

How to Deal Dangerous Proteins a Knockout Blow

In the genteel game of croquet, the goal is deceptively straightforward: to hit your ball through a series of hoops before your opponent does. However, anyone who has picked up a mallet knows the sport can get downright cutthroat. A strong player with the right strategy can hit her opponent’s...

Banking on the British Exome

Banking on the British Exome

Banking on the British Exome

The vast UK Biobank is a treasure trove of genetic data. Scientists are mining it now for potential therapeutic gems.  ...

Medical Match: Recruiting the Right Patients for Experimental Treatments

Medical Match: Recruiting the Right Patients for Experimental Treatments

Medical Match: Recruiting the Right Patients...

Most people first become aware of clinical trials when they are out of standard treatment options for a health problem and they learn about an experimental drug either through their own research, a recommendation from their doctor or a specialist, or a suggestion from a loved one. ...

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