Enable JavaScript to visit this website.

Disruptive Science

Helping the Liver Help Itself

Helping the Liver Help Itself

Helping the Liver Help Itself

Humans have practiced medicine for thousands of years, but the earliest results were decidedly mixed. Archaeological evidence reveals prehistoric physicians performed complicated tasks such as neurosurgery as far back as the Neolithic age. However, the evidence also suggests that prehistoric...

Unlocking the Secrets of a Protein “Superfamily

Unlocking the Secrets of a Protein “Superfamily"

Unlocking the Secrets of a Protein “Superfamily"

Large families can be complex. And while you may know some of its members individually, you can’t really gain a true understanding of their relationships and dynamics without considering the group in its totality. ...

Matching Drugs to Diseases: Advances in Targeting JAKs Leading to New Autoimmune Therapies

Matching Drugs to Diseases: Advances in Targeting JAKs Leading to New Autoimmune Therapies

Matching Drugs to Diseases: Advances in...

Janus kinases (JAKs) named after Janus, the Roman two-faced god of duality, are enzymes with two “faces,” or domains, that play a key role in signal transduction of cytokines, the molecular messengers that trigger the inflammatory and immune responses. Scientific discoveries related to JAKs...

Using DNA ‘Barcodes’ in the Search for New Drugs

Using DNA ‘Barcodes’ in the Search for New Drugs

Using DNA ‘Barcodes’ in the Search for New Drugs

Organic lettuce, endangered sharks, and now, new medicines. ...

Inside the Toxicology Lab: From Guardians of the Genome to Bottleneck Breakers and Beyond

Inside the Toxicology Lab: From Guardians of the Genome to Bottleneck Breakers and Beyond

Inside the Toxicology Lab: From Guardians of...

When it comes to creating new medicines, the stories that most often reach the public are the discoveries of new biological pathways or novel compounds. But in the nearly decade-long journey a medicine takes to get from the lab to patients, drug safety studies are an integral, though often behind...

How Quantum Physics and AI is Disrupting Drug Discovery & Development

How Quantum Physics and AI is Disrupting Drug Discovery & Development

How Quantum Physics and AI is Disrupting Drug...

Thanks to a recent strategic research collaboration with XtalPi, a U.S.-China pharmaceutical tech company, Pfizer scientists are performing crystal structure prediction in a matter of days. Pioneered by a group of quantum physicists from MIT, the XtalPi technology leverages artificial...

What an Artificial Eating Machine Can Teach Us About Medications

What an Artificial Eating Machine Can Teach Us About Medications

What an Artificial Eating Machine Can Teach Us...

The old saying “you are what you eat” may not be strictly accurate, but like many a timeworn adage, it holds a kernel of truth. For example, while eating a high-fat diet may not necessarily make people fat, the amount and type of fat in their diets still influences their overall health. When...

In Search of a Better Biomarker: Why Studying Liver Enzymes Matters for Drug Safety

In Search of a Better Biomarker: Why Studying Liver Enzymes Matters for Drug Safety

In Search of a Better Biomarker: Why Studying...

If you’ve ever had a liver function test as part of an annual physical, you may know that the exam screens for certain biomarkers, like liver enzymes in the blood. If these substances are found to be elevated, it may mean that you have a liver disease or have been exposed to some medications or...

Quantifying Matters of the Heart: Using Mathematical Modeling to Simulate Vital Organs

Quantifying Matters of the Heart: Using Mathematical Modeling to Simulate Vital Organs

Quantifying Matters of the Heart: Using...

Songwriters, poets, and novelists have long tried to capture the intricacies of the heart. But it’s the quants who might finally do it.  ...

Get the Latest Updates