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Disruptive Science

Using the Dr. Jekyll of Chemical Compounds to Advance Drug Synthesis

Using the Dr. Jekyll of Chemical Compounds to Advance Drug Synthesis

Using the Dr. Jekyll of Chemical Compounds to...

Sulfuryl fluoride gas is the chemical equivalent of Mr. Hyde. Like the fictional monster, it’s dangerous and difficult to work with. But by inventing a process that creates a new substance called [4-(Acetylamino)phenyl]-ImidodiSulfuryl diFluoride, referred to as AISF, scientists are replacing the...

The ‘Ecology’ of Cancer: Studying the ‘Soil’ that Enables the Disease to Thrive

The ‘Ecology’ of Cancer: Studying the ‘Soil’ that Enables the Disease to Thrive

The ‘Ecology’ of Cancer: Studying the ‘Soil’...

Borrowing from the field of ecology, cancer is now being examined in terms of the relationship between a cancer cell and the traits of its local environment — the tissue, cells and blood vessels — that help it to thrive. ...

How to Deal Dangerous Proteins a Knockout Blow

How to Deal Dangerous Proteins a Knockout Blow

How to Deal Dangerous Proteins a Knockout Blow

In the genteel game of croquet, the goal is deceptively straightforward: to hit your ball through a series of hoops before your opponent does. However, anyone who has picked up a mallet knows the sport can get downright cutthroat. A strong player with the right strategy can hit her opponent’s...

Banking on the British Exome

Banking on the British Exome

Banking on the British Exome

The vast UK Biobank is a treasure trove of genetic data. Scientists are mining it now for potential therapeutic gems.  ...

Medical Match: Recruiting the Right Patients for Experimental Treatments

Medical Match: Recruiting the Right Patients for Experimental Treatments

Medical Match: Recruiting the Right Patients...

Most people first become aware of clinical trials when they are out of standard treatment options for a health problem and they learn about an experimental drug either through their own research, a recommendation from their doctor or a specialist, or a suggestion from a loved one. ...

Clinical Trials Meet the 'Real World'

Clinical Trials Meet the 'Real World'

Clinical Trials Meet the 'Real World'

As data sources proliferate, researchers are incorporating real world evidence in clinical trials.  ...

Treating Disease with 'Precision Medicines' that Target Specific Patients

Treating Disease with 'Precision Medicines' that Target Specific Patients

Treating Disease with 'Precision Medicines'...

When people talk about curing cancer, an oncologist’s reaction likely is: What kind of cancer? If you answer “breast cancer,”  the oncologist will likely want to know which of its many varieties do you mean?  ...

 Could Diversity in Clinical Trials Be the Key to Understanding Liver Disease? 

Could Diversity in Clinical Trials Be the Key to Understanding Liver Disease? 

Could Diversity in Clinical Trials Be the Key...

In a New Yorker article about how evolutionary psychology findings are usually based on surveys of undergraduates, Anthony Gottlieb wrote, “American college kids, whatever their charms, are a laughable proxy for Homo sapiens.”  ...

Patients as Partners in Developing New Medicines

Patients as Partners in Developing New Medicines

Patients as Partners in Developing New Medicines

With a growing emphasis on patient-reported outcomes, study volunteers are becoming active participants in evaluating a treatment’s efficacy. ...

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