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Disruptive Science

The Rise of RNA: The Cellular Workhorse Behind a New Class of Next-Gen Therapies

The Rise of RNA: The Cellular Workhorse Behind a New Class of Next-Gen Therapies

The Rise of RNA: The Cellular Workhorse Behind...

In a new Get Science series, we’re exploring how recent insights into RNA’s role in a variety of biological processes are helping scientists develop promising scientific breathroughs that may lead to new medicines for diseases, such as cancer and autoimmune conditions. ...

The Table of Everything: A Scientist’s Quest to Make Human Genetic Data More User-Friendly

The Table of Everything: A Scientist’s Quest to Make Human Genetic Data More User-Friendly

The Table of Everything: A Scientist’s Quest to...

Since the human genome was first sequenced in 2003, scientists have collected a wealth of genetic information that could potentially be used to help create new medicines. Remarkably, as sequencing technology gets faster and cheaper, the amount of human genetic data now doubles every seven months....

The Future of Flu Season: How RNA Technology Could Revolutionize Vaccine Production

The Future of Flu Season: How RNA Technology Could Revolutionize Vaccine Production

The Future of Flu Season: How RNA Technology...

Every year, millions of people get the flu shot. Although the vaccine provides protection for many people, some people still get the flu, in part, because the influenza vaccine production cycle starts at least six months in advance of the flu season. And while the World Health Organization’s...

Partnering to Turn the 'Undruggable' into Promising Targets

Partnering to Turn the 'Undruggable' into Promising Targets

Partnering to Turn the 'Undruggable' into...

In the world of drug discovery, “undruggable” targets are like the stubborn children of biology, proteins that are considered too challenging to bind with conventional molecules. With the rapid pace of scientific advancement, however, the “undruggable” targets of yesterday now represent a...

Meet the Team: Homegrown Therapies Get Ready to Fight NASH

Meet the Team: Homegrown Therapies Get Ready to Fight NASH

Meet the Team: Homegrown Therapies Get Ready to...

One of the biggest public health problems of our time is likely soon to face off with a new wave of cutting-edge medicines. As non-alcoholic steatohepatitis (NASH), a severe form of non-alcoholic fatty liver disease, or NAFLD, continues to be a growing public health threat, scientists are racing...

How Next-Generation Sequencing Is Helping to Build Better Vaccines

How Next-Generation Sequencing Is Helping to Build Better Vaccines

How Next-Generation Sequencing Is Helping to...

If you’ve ever tried an at-home genetic testing kit, you’re familiar with whole-genome sequencing, the technology that allows people to quickly and easily map their DNA. This same technology is now being used to track the genomes of potentially deadly microbes. ...

Capturing the Itch: Using Digital Wearable Devices to Help Patients with Atopic Dermatitis

Capturing the Itch: Using Digital Wearable Devices to Help Patients with Atopic Dermatitis

Capturing the Itch: Using Digital Wearable...

For people who have atopic dermatitis (AD) — an autoimmune condition that causes painful, itchy, and inflamed skin — symptoms often flare up at night, leading to disrupted sleep. Until recently, there hasn’t been a way to truly capture how much a person’s quality of life is impacted by these...

Designing Medicines to Go Where They're Needed: Lessons from Liver Targeting

Designing Medicines to Go Where They're Needed: Lessons from Liver Targeting

Designing Medicines to Go Where They're Needed:...

Designing transformational medicines for patients requires them to be efficacious and safe.  Sometimes, drug molecules have the desired effect in the organ of treatment and undesired effects in other organs, meaning one way to achieve a safer medicine is through directing the drug molecule to the...

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