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Disruptive Science

What an Artificial Eating Machine Can Teach Us About Medications

What an Artificial Eating Machine Can Teach Us About Medications

What an Artificial Eating Machine Can Teach Us...

The old saying “you are what you eat” may not be strictly accurate, but like many a timeworn adage, it holds a kernel of truth. For example, while eating a high-fat diet may not necessarily make people fat, the amount and type of fat in their diets still influences their overall health. When...

In Search of a Better Biomarker: Why Studying Liver Enzymes Matters for Drug Safety

In Search of a Better Biomarker: Why Studying Liver Enzymes Matters for Drug Safety

In Search of a Better Biomarker: Why Studying...

If you’ve ever had a liver function test as part of an annual physical, you may know that the exam screens for certain biomarkers, like liver enzymes in the blood. If these substances are found to be elevated, it may mean that you have a liver disease or have been exposed to some medications or...

Quantifying Matters of the Heart: Using Mathematical Modeling to Simulate Vital Organs

Quantifying Matters of the Heart: Using Mathematical Modeling to Simulate Vital Organs

Quantifying Matters of the Heart: Using...

Songwriters, poets, and novelists have long tried to capture the intricacies of the heart. But it’s the quants who might finally do it.  ...

Scientist Embraces the ‘Ick’ Factor to Develop a New Tool Against a Dangerous Pathogen

Scientist Embraces the ‘Ick’ Factor to Develop a New Tool Against a Dangerous Pathogen

Scientist Embraces the ‘Ick’ Factor to Develop...

Developing a vaccine to prevent the devastating disease caused by Clostridium difficile requires a reliable and sensitive test to diagnose the dangerous disease causing toxins produced by C. diff — and it also required scientists to figure out how to detect the toxins in stool...

That Which is Old is New Again: Phenotypic Drug Discovery Makes a Comeback

That Which is Old is New Again: Phenotypic Drug Discovery Makes a Comeback

That Which is Old is New Again: Phenotypic Drug...

Scientists return to a classic model of drug discovery in an attempt to find novel medicines, while adding a modern spin. ...

Tumor-Typing: A New Way of Assessing Cancer Treatment Options

Tumor-Typing: A New Way of Assessing Cancer Treatment Options

Tumor-Typing: A New Way of Assessing Cancer...

A method of analyzing tumors could inform response to immunotherapies.  ...

Attacking Cancer Cells That Develop Resistance

Attacking Cancer Cells That Develop Resistance

Attacking Cancer Cells That Develop Resistance

When cancer patients receive therapy for an extended time, they often face the specter of drug resistance as tumor cells mutate and find ways to evade the cancer-killing medicines. ...

Using the Dr. Jekyll of Chemical Compounds to Advance Drug Synthesis

Using the Dr. Jekyll of Chemical Compounds to Advance Drug Synthesis

Using the Dr. Jekyll of Chemical Compounds to...

Sulfuryl fluoride gas is the chemical equivalent of Mr. Hyde. Like the fictional monster, it’s dangerous and difficult to work with. But by inventing a process that creates a new substance called [4-(Acetylamino)phenyl]-ImidodiSulfuryl diFluoride, referred to as AISF, scientists are replacing the...

The ‘Ecology’ of Cancer: Studying the ‘Soil’ that Enables the Disease to Thrive

The ‘Ecology’ of Cancer: Studying the ‘Soil’ that Enables the Disease to Thrive

The ‘Ecology’ of Cancer: Studying the ‘Soil’...

Borrowing from the field of ecology, cancer is now being examined in terms of the relationship between a cancer cell and the traits of its local environment — the tissue, cells and blood vessels — that help it to thrive. ...

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