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Disruptive Science

From Flask to Vat: The Challenges of Scaling Up Gene Therapy

From Flask to Vat: The Challenges of Scaling Up Gene Therapy

From Flask to Vat: The Challenges of Scaling Up...

Over the past two decades, gene therapy has been incubating at a very small scale in academic research labs. Like a chef fine-tuning a new recipe, scientists have been working in single batches that would only be sufficient to treat one or two patients at a time....

Hope in Translation: Bringing Gene Therapy to the Clinic

Hope in Translation: Bringing Gene Therapy to the Clinic

Hope in Translation: Bringing Gene Therapy to...

In 1987, scientists first uncovered the gene that is the target of mutations that causes Duchenne muscular dystrophy (DMD), a lethal muscle-wasting disease that affects about one in every 5,000 newborn boys. While the discovery of...

Inside

Inside "Custom Cars” For Gene Delivery

Inside "Custom Cars” For Gene Delivery

Gene therapy shows great promise to be potentially transformational treatments for a number of single-gene disorders, such as Duchenne muscular dystrophy, hemophilia and cystic fibrosis. ...

Bespoke Is Often Better: How Scientists Are Customizing Gene Therapy

Bespoke Is Often Better: How Scientists Are Customizing Gene Therapy

Bespoke Is Often Better: How Scientists Are...

When it comes to products from suits to kitchen cabinetry, bespoke often means better. That’s because custom-designed goods are more likely to fit your specific needs. ...

Breathing New Life Into Lung Cancer Research

Breathing New Life Into Lung Cancer Research

Breathing New Life Into Lung Cancer Research

The story of cancer was long seen as a single narrative: a cell acquires genetic mutations, starts to divide uncontrollably and then spreads. ...

New RNA Technology Could Get the Flu Vaccine Right, Every Year

New RNA Technology Could Get the Flu Vaccine Right, Every Year

New RNA Technology Could Get the Flu Vaccine...

We’ve been making the flu vaccine in nearly the same way for 70 years. A new technology based on RNA could disrupt that. ...

What is Green Chemistry?

What is Green Chemistry?

What is Green Chemistry?

The way contemporary chemists work is a lot different than the way their predecessors worked only a few generations ago. You might think that the change is due to new technologies or breakthroughs in scientific understanding, but that’s only partly right. One of the major reasons chemistry is...

Scientific ‘Swap Meet’: Pharma Competitors Form Novel Consortium to Share Materials

Scientific ‘Swap Meet’: Pharma Competitors Form Novel Consortium to Share Materials

Scientific ‘Swap Meet’: Pharma Competitors Form...

Just as an amazing meal often begins with the best ingredients, the most innovative compounds are likely to emerge when scientists have access to diverse and high-quality chemical building blocks. ...

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